HIV - 1 and HIV - 2 Vif Interact with Human APOBEC 3 Proteins Using Completely 1 Different Determinants
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چکیده
HIV-1 and HIV-2 Vif Interact with Human APOBEC3 Proteins Using Completely 1 Different Determinants 2 Jessica L. Smith, Taisuke Izumi, Timothy C. Borbet, Ariel N. Hagedorn, and Vinay K. Pathak* 3 Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National 4 Cancer Institute, Frederick, MD 21702, USA 5 6 Running title: HIV-2 Vif-APOBEC3 interactions 7 8 *Address Correspondence to: Vinay K. Pathak, [email protected]. 9 10 11 Abstract word count: 227 12 Text word count: 12,050 13 JVI Accepts, published online ahead of print on 18 June 2014 J. Virol. doi:10.1128/JVI.01318-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
HIV-1 and HIV-2 Vif interact with human APOBEC3 proteins using completely different determinants.
UNLABELLED Human APOBEC3 (A3) restriction factors provide intrinsic immunity against zoonotic transmission of pathogenic viruses. A3D, A3F, A3G, and A3H haplotype II (A3H-hapII) can be packaged into virion infectivity factor (Vif)-deficient HIVs to inhibit viral replication. To overcome these restriction factors, Vif binds to the A3 proteins in viral producer cells to target them for ubiquitina...
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The multidomain HIV-1 Vif protein recruits several cellular partners to achieve neutralization of the antiviral activity of APOBEC3 proteins. Vif neutralizes APOBEC3G and APOBEC3F predominantly by forming an E3 ubiquitin ligase with Cullin5, ElonginB and ElonginC that targets these proteins for degradation by the ubiquitin-proteasome pathway. Vif associates with the Cullin5-ElonginB-ElonginC co...
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Human APOBEC3F (hA3F) and human APOBEC3G (hA3G) are potent anti-human immunodeficiency virus (anti-HIV) host factors that suppress viral replication by hypermutating the viral genome, inhibiting reverse transcription, and hindering integration. To overcome hA3F and hA3G, HIV-1 encodes Vif, which binds and targets these host proteins for proteasomal degradation. Previously, we reported that the ...
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BACKGROUND APOBEC3G (A3G) and related cytidine deaminases of the APOBEC3 family of proteins are potent inhibitors of many retroviruses, including HIV-1. Formation of infectious HIV-1 requires the suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through the common mechanism of recruiting the Cullin5-ElonginB-ElonginC E3 ubiquitin ligase to induce ...
متن کاملIdentification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F.
Human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) inhibit replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their proteasomal degradation. The Vif-A3G and Vif-A3F interactions are attractive targets for antiviral drug development because inhibiting the interactions could allow th...
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